Ciprofloxacin 500 mg & Ordinazole 500 mg Tablets
Composition of Ciprofloxacin 500 mg:
Each film-coated tablet contains: Ciprofloxacin Hydrochloride BP to Ciprofloxacin 500 mg. Ordinazole 500mg. Excipients Q.S.
Colour: Titanium Dioxide BP & Ferric oxide yellow USP NF
About Ornidazole & Ciprofloxacin
Ornidazole :A nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.
Ciprofloxacin:lt is a broad-spectrum fluoroquinolone with activity against Pseudomonas aeruginosa.
Mechanism of Action of Ornidazole & Ciprofloxacin
Ornidazole:
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Ciprofloxacin
Ciprofloxacin is bacteriostatic at low concentrations and bactericidal at high concentrations. It acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4. DNA gyrase helps in the formation of a highly condensed three-dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil into the DNA double helix. Ciprofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibit the transcription of DNA into RNA and subsequent protein synthesis.
Pharmacokinets of Ornidazole & Ciprofloxacin
Ornidazole:
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in the liver by conjugation, Excretion: Excreted in urine and a small portion is excreted in bile
Ciprofloxacin:
Absorption: They are adequately absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes hepatic metabolism.
Excretion: The drug is excreted mainly through urine.
Side Effects of Ornidazole & Ciprofloxacin
- Abdominal pain
- Vertigo
- Nausea
- Vomiting
- Fatigue
- Dry mouth
- Headache
- Rash
- Urticaria
- Abdominal
- distress
- Dizziness
- Vertigo
- Diarrhoea
- Restlessness
- Drowsiness
- Arthralgia
- Confusion
- Insomnia
- Anorexia
- Bad taste
- Photosensitivity
Contra-indications of Ornidazole & Ciprofloxacin
Hypersensitivity to the drug or other imidazoles & Hypersensitivity to Ciprofloxacin and other Fluoroquinolones
Special Precautions while taking Ornidazole & Ciprofloxacin
1. Vertigo
2. Mental confusion
3. Ataxia
4. Hepatic impairment
5. Renal impairment
6. Epilepsy
7. Dehydration
Indications for Ornidazole & Ciprofloxacin
- Amoebiasis
- Giardiasis
- Trichomonas
- vaginitis
- Anaerobic bacterial infections
- Bacterial vaginosis
- Respiratory tract infection
- Bone and joint infections,
- Infectious diarrhoea
- Gonorrhoea
- ENT infections
- Skin and soft tissue infections
- Typhoid fever
- Intra-abdominal infections
- Prostatitis
- Sinusitis
- Chancroid
- Gynaecological infections
- Tularemia
Antacids (aluminium/magnesium hydroxide), Iron salts, Zinc salts.: Absorption of ciprofloxacin is decreased.
Antineoplastic drugs: Decrease serum levels of ciprofloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anti-coagulants: Enhanced efficacy of anti-coagulants.
Cyclosporine: Nephrotoxicity increased by ciprofloxacin.
Theophylline: Increased plasma levels of theophylline result in toxicity.
NSAIDs: CNS excitation may occur.
Rifampicin: Decreases serum concentration of ciprofloxacin.
Chloramphenicol: Antagonises effects of ciprofloxacin.
Typical Dosage for Ornidazole
- Amoebiasis: Adults: 1 gm daily in 2 divided doses for 7 to 10 days Children: 10 to 25mg/kg once daily for 3days
- Amoebic dysentery: Adults: 1.5gm once daily for 3 days Children: 40mg/kg once daily for 3 days Trichomoniasis
- Adults: 1.5gm single daily dose or 0.5gm 12 hourly for 5 days,
- Male partners should be concurrently treated.
- Children: 25mg/kg as a single dose Giardiasis:
- Adults: 1 to 1.5gm once daily for 2days Children: 40mg/kg for 2days
- Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Typical Dosage for Ciprofloxacin
Adults:
The dose is determined on the basis of the severity of the infection, type of infecting organism, age, weight and renal function of the patient.
UTI: 0.5 – 1 g / day in 2 divided doses.
Respiratory tract infection, Bone and joint infections, Infectious diarrhoea, ENT infections, .Skin and soft tissue infections, Enteric fever: 1 – 1.5 g / day in 2 divided doses
Typhoid fever, Intra-abdominal infections, Gynaecological infection: 1 g / day in 2 divided doses Uncomplicated gonorrhea: 250 mg /day.
Storage:
Store below 30°C. Protect from light and moisture.
Keep the medicine out of reach of children.
Presentation: 10 Tablets
Marketed by:
PYXUS PHARMACEUTICALS PVT. LTD.
